52 Intisari Paten Efek Terapetik Tahitian Noni

Tahitian Noni Bioactive Beverage, dengan 52 paten dan 15 uji klinis, memiliki keunggulan dasar ilmiah kuat yang tidak dimiliki oleh produk suplemen maupun produk CAM (Complementary and Alternative Medicine - Pengobatan Komplementer dan Alternatif) manapun. Produk-produk Tahitian Noni  telah mendapatkan 52 Sertifikasi Hak Paten International. Prestasi ini diluar kelaziman produk-produk nonfarmasi, dan tentunya diluar persepsi publik kesehatan dewasa ini.

Berikut daftar hak paten terapetik yang telah dikantongi Tahitian Noni International :

A. ANTINEOPLASTIC (Anti pembentukan jaringan baru)

1.  Pencegahan kanker

Cancer Preventive Effect of Morinda citrifolia. International Publication Number WO 02/45654. Su, Chen et al. PCT 2002; p.1-20.

2.  Penghambatan metastasis sel karsinogenik 

Morinda citrifolia – Based Information for Inhibiting Metastasis of carcinogenic cells. International Publication Number WO 2004/098514. Su Chen et al. PCT 2004; p.1-32.

3.  Anti pembentukan pembuluh darah yang abnormal terkait kasus kanker 

Anti-Angiogenesis Effect of Morinda citrifolia . International Publication Number WO 2004/041186. Palu, Afa et al. PCT 2004; p.1-24.

4.  Menghambat terjadinya Angiogenesis dan merusak pembuluh darah Angiogenik

Inhibition of Angiogenesis and Destruction of Angiogenic Vessel with Extracts of Noni Juice (Morinda citrifolia ). International Publication Number WO/020296. Woltering Eugene et al. PCT 2003; p.1-47.

5.  Menghambat enzim metalloproteinase yang dapat menyebabkan tumor

Morinda citrifolia L. Based Formulations for Inhibiting Matrix Metalloproteinase Enzymes. United States Patent Application Ser. No. 20070184137. Palu, Afa et al. USPTO 2007

6.  Mencegah kanker

Synergistic Cancer Prevention Effect of Morinda citrifolia . International Application Number 2004/029896. Wang, Mian et al. PCT 2004; p.1-21.

7.  Mencegah kanker payudara

Preventative Effect of Morinda citrifolia on Mammary Breast Cancer. International Publication Number WO 2005/048919. Wang, Mian et al.PCT 2005; p.1-17.

8.  Pengobatan dan pencegahan kanker payudara 

Formulation and Methods for Treating Breast Cancer with Morinda citrifolia and Methylsulfonymethane. International Publication Number WO 2005/025410. Wang, Mian et al. PCT 2005; p.1-41.

9.  Mencegah dan menghambat pertumbuhan sel kanker usus 

Preventative and treatment effects of Morinda citrifolia as colon cancer cell growth inhibitor. United States Patent Application Ser. No. 7,070,813. Jasen, Jarake et al. USPTO 2006.

10.  Menghambat pembentukan enzim Aromatase terkait dengan penyakit yang berhubungan dengan hormon estrogen 

Preventative and Treatment Effects of Morinda citrifolia as an Aromatase Inhibitor. United States Patent Application Ser. No. 10/396,868. Palu, Afa et al. USPTO 2004; p.1-48.

11.  Mengobati kerusakan liver akibat paparan CCl4 dari pestisida, fumigan, pernis, dll.  

Method for Treating Carbon Tetra-Chloride Induced Liver Damage by Administering Morinda citrifolia. United States Patent Application Ser. No. 20030086990. Jensen Jarake et al. USPTO 2003; p.1-12.

12. Kanker Prostat

54th Patent. Prostate Cancer. Patent pending in US (not yet published).

13.  Ekstrak tanaman Noni untuk pengobatan kanker lambung dan liver 

Extract of the Noni Plant are Listed as Useful for Treatment of Cancer of the Stomach and Liver. JP 8208461. (not yet publish).

B. ANTIINFLAMMATORY, ALLERGIC & ANTINOCICEPTIVE (Anti-Inflamasi, Anti-alergi, dan Anti-nosiseptif)

14.  TAHITIAN NONI® JUICE sebagai inhibitor selektif COX-2 

TAHITIAN NONI® JUICE on COX-1 and COX-2 and TAHITIAN NONI® Juice as a selective COX-2 Inhibitor. International Publication Number WO 02/45734. Su Chen et al. PCT 2002; p.1-14.

15.  Menghambat enzim 5-LOX dan 15-LOX terkait penyakit inflamasi 

Morinda citrifolia – Based Information 5-LOX and 15-LOX. International Publication Number WO 2005/ 120538. Palu, Afa et al. PCT 2005; p. 1-34.

16.  Menghambat enzim Lipoksigenase dan Siklooksigenase 

Lipoxygenase and Cyclooxygenase Inhibition. International Publication Number WO 2008/067410. Deng, Sixhin et al. PCT 2008; p.1-31.

17.  Sebagai Anti-Inflamasi melalui penghambatan terhadap COX-1, COX-2, Interleukin-1?, Interleukin-6, TNF-?, HLE, iNOS 

Morinda citrifolia Based Composition for Treatment of Anti-Inflammatory Diseases through Inhibition of COX-1, COX-2, Interleukin-1?, Interleukin-6, TNF-?, HLE, iNOS. International Publication Number WO 2007/076024. Zhou, Bing et al. PCT 2007; p.1-52.

18.  Menghambat enzim Xantin Oksidase (terkait dengan penyakit asam urat) 

Morinda citrifolia Based Composition and Method for Inhibiting Xantine Oxidase. International Publication Number WO 2006/050012. Palu, Afa et al. PCT 2006; p.1-25.

19.  Pencegahan dan pengobatan osteoarthritis dan kondisi sejenisnya 

Preventative and treatment effect of Morinda citrifolia on Osteoarthritis and Its Related Conditions. United States Patent Application Ser.No.7,033,624. Jesen, Jarake et al. USPTO 2006; p.1-21.

20.  Menghambat terjadinya phosphodiesterase terkait dengan menurunnya energi tubuh, alergi dan asma 

Methods and Formulation for Inhibiting Naturally occurring Phosphodiesterase. United States Patent Application Ser.No.20070248701.

C. ANTIFUNGAL/MICROBIAL & ANTIVIRAL (Anti-Jamur/Mikroba dan Anti Virus)

21. Formulasi dan Metode Anti Jamur 

Morinda citrifolia Based Antifungal Formulation and Methods. International Publication Number WO 2006/104892. Isami, Fumiyuki et al.

22.  Efek sebagai anti-jamur 

Antifungal Effects of Morinda citrifolia . International Publication Number WO 2003/099310. Gerson, Scott et al.

23.  Menghambat pertumbuhan jamur dan mikroba 

Formulation for Inhibiting Fungal and Microbial Growth Comprising Morinda citrifolia Puree Juice. United States Patent Application Ser.No.7,048,952.

24.  Pengobatan terhadap Candidiasis 

Methods and Formulation for Treating Candidiasis Using Morinda citrifolia. United States Patent Application Ser.No.7,014,873.

25.  Formulasi dan Metode Anti Virus 

Antiviral Morinda citrifolia L. Based Formulations and Methods of Administration. International Publication Number WO 2007/064601. Palu, Afa et al.

26.  Ekstrak tanaman Noni untuk pengobatan Hepatittis B dan AIDS  

Use of Plant Extract from Noni for Treatment of Hepatitis B and AIDS. International Publication Number WO 88053043. (Not yet published).

27.  Ekstrak noni untuk pengobatan Hepatitis

Extract of Noni as Useful Treatment of Hepatitis. JP No.62132829. (Not yet published).

28.  Ekstrak noni sebagai penghambat proliferasi pada HIV  

Extract of Noni as an Inhibitor of Proliferation of HIV. JP No.6087737. (Not yet published).

29.  Ekstrak tanaman noni untuk pengobatan Infeksi Saluran Pernafasan Atas (ISPA) yang disebabkan bakteri Helicobacter pylori  

Extract of Noni Plant to Treat the Recurring Infection of the Upper Respiratory Tract Caused by Helicobacter pylori. JP No.8217686. (Not yet published).

D. DEGENERATIVE DISORDER & ADDICTION THERAPIES (Penyakit Degeneratif dan Terapi Adiksi)

30.  Menghambat enzim Monoamine Oksidase (MAO) dan Cathechol-O-Methyltransferase (COMT) (terkait dengan penyakit mental/saraf)

 Methods and Composition for Inhibiting Monoamine Oxidase and Catechol-O-Methyltransferase. International Publication Number WO 2005/086937. Palu, Afa et al.

31.  Mengaktifkan enzim Asetilkolinesterase (terkait dengan sistem saraf)  

Methods and Composition for Reactivating Acetylcholinesterase. International Publication Number WO 2005/086834. Palu, Afa et al.

32.  Mengobati dan mencegah sakit kepala migrain 

Morinda citrifolia Enhanced Naturaceutical Formulation and Method for Treating and Preventing Migraine Headaches. United States Patent Application Ser.No.20030108630. Story, Stephen et al.

33.  Mengobati kerusakan visual (glaucoma, diabetes retinopathy, katarak, rabun senja, buta warna, dan sejenisnya)

 Method for Treating Visual Impairment through the Prophylactic Administration of Morinda citrifolia -Based Naturaceutical. United States Patent Application Ser.No.20030134002. Jensen,Jarake Ocampo Enreque.

34.  Antagonis reseptor Nikotin Asetilkolin (terkait dengan kondisi kecanduan rokok/nikotin) 

Nicotinic Acetylcholine Receptor Antagonist. United States Patent Application Ser.No.20060280818. Palu, Afa et al.

35.  Mencegah dan mengobati penyalahgunaan obat dan adiksi terhadap obat 

Formulations and Methods for Preventing and Treating Substance Abuse and Addiction. United States Patent Application Ser.No.20070166416. Palu, Afa et al.

36.  Menghambat pembentukan Angiotensin dan enzim Chymase (terkait dengan tekanan darah) 

Methods and Composition for Inhibiting Angiotensin Converting and Chymase Enzymes. International Publication Number WO 2005/086935.

37.  Penggunaan komposisi Morinda citrifolia 

Use of a Composition. International Publication Number WO 01/64231.

38.  Menghambat Histone Deactylase (HDAC) dan Tumor Necrosis Converting Enzyme (TACE) (terkait dengan tumor atau kanker)  

Histone Deacetylase and Tumor Necrosis Factor Converting Enzyme Inhibition. European Patent Application No.1726309. Palu, Afa et al. EP.

E. INDUCE METABOLISM BALANCE & REPRODUCTION SYSTEM (Meningkatkan keseimbangan metabolisme & sistem reproduksi)

39.  Diabetes tipe II 

Type II Diabetes. International Publication Number WO 2005/067489. Palu, Afa et al.

40.  Mencegah dan mengobati Diabetes 

Preventative and Treatment Effects of Morinda citrifolia L. on Diabetes and Its Related Conditions. United States Patent Application Ser. No.7,186,422.

41.  Serbuk buah noni untuk mengobati diabetes, masalah jantung, hipertensi, masalah menstruasi, demam, dan nyeri 

A Palatable Noni Fruit Powder that Can be Use to Treat Diabetes, Heart Trouble, High Blood Pressure, Menstrual Problems, Fever, Aches, and Pains. States Patent Application Ser.No.5,288,491. USPTO. (Not yet publish).

42.  Sebagai serat diet 

Morinda citrifolia Dietary Fiber. International Publication Number WO 01/15551. Wadsworth, John et al.

43.  Dapat untuk mengontrol berat badan 

Morinda citrifolia Based Formulation and Methods for Weight Management. International Publication Number WO 2007/064547. Palu, Afa et al. PCT.

44.  Mengurangi Oksiterol dalam darah terkait kadar kolesterol dan tekanan darah 

Composition and Methods for Reducing Oxysterol in Blood. International Publication Number WO 02/056899. Yegorova, I.

45.  Memperbaiki profil Lipid Protein (LDL dan HDL) dan menghambat enzim HMG-CoA reduktase 

Improving Profiles of Lipid Protein and Inhibiting HMG-CoA Reductase. International Publication Number WO 2005/069844. Palu, Afa et al. PCT.

46.  Menghambat secara selektif produksi hormone estrogen (terkait dengan kanker payudara)  

Selectively Inhibiting Estrogen Production and Providing Estrogenic Effects in the Human Body. International Publication Number WO 2004/091545.

47.  Digunakan dalam bidang spermatologi dan metode untuk meningkatkan daya tahan sperma. 

Use of Morinda citrifolia (Noni) Extract in the field of Spermatology and Method for Improving Sperm Preservation. International Publication Number WO 2008/032132. Kutvolgyi, Gabriella.

48.  Meningkatkan kadar hormon Testosteron dan hormon pertumbuhan

Composition for Increasing Levels of Hormones and a Method for Preparation of Said Composition.International Publication NumberWO 2005/084681.

F. ORAL CARE & DERMATOLOGICAL THERAPIES (Terapi oral dan dermatologi)

49.  Untuk perawatan oral (untuk kesehatan gigi dan gusi) 

Morinda citrifolia Based Oral-Care Composition and Methods. International Publication Number WO 2005/030141. Jesen, Jarake et al. PCT 2005; p.1-60.

50.  Pengobatan penyakit oral 

Use of Noni in Relation to Oral Pathologies for Example in order to Combat Problems Associated with Asialia and Hyposilia. International Publication Number WO 2005/018655. Vein Jean, D’arros Gerard. PCT 2005; p.1-20.

51.  Pengobatan kerusakan dermatologi (masalah kulit)

Methods and Composition for Treating Dermatological Disorder with Morinda citrifolia. United States Patent Application Ser.No.20030091666. Murad Howard et al. USPTO 2003; p.1-20.

52.  Untuk kosmetik, sebagai repair serum 

Cosmetic intensive repair serum with Morinda citrifolia. United States Patent Application Ser.No.6,589,514. Jensen Jarake, et al. USPTO 2003; p.1-21.

53.  Untuk perawatan bibir

Morinda citrifolia Enhanced Lip Treatment. United States Patent Application Ser.No.20030086989. Jensen Jarake, Robinson Heidi. USPTO 2003; p.1-12.

G. THERAPEUTIC & PALLIATIVE JUICE COMPOSITION (Terapi jus dan paliatif)

54.  Jus terapi untuk wanita 

Therapeutic Juice Composition for Woman. United States Patent Application Ser.No.20070122502. Lawrence M. USPTO 2007; p.1-12.

55.  Jus daun dan ekstrak daun Morinda citrifolia 

Morinda citrifolia Leaf Juice and Leaf Extract Based Formulations. International Publication Number WO 2007/064521. Palu Afa et al. PCT 2007; p.1-47.

56.  Pemberian senyawa bioaktif dari Morinda citrifolia 

Method and Composition for Administering Bioactive Compounds Derived from Morinda citrifolia . International Publication Number WO 2007/134205. Zhou Bing et al. PCT 2007; p.1-27.

57.  Ekstrak noni untuk pencegahan penyakit (antara lain : Hipertensi, asma, diabetes, kram haid, diare & penyakit pada saluran kencing dan nafas) 

Noni Extract for Prevention of Disease. United States Patent Application Ser.No.20030004116. Ghai Gheetha et al. USPTO 2003; p.1-8.

58.  Efek paliatif Morinda citrifolia terkait penyakit kanker, Alzheimer, penyakit berbasis inflamasi

 Palliative Effects of Morinda citrifolia Oil and Juice. International Publication Number WO 02/083159. Jensen Jarake et al. PCT 2003; p.1-14.

59.  Metode untuk proses tanaman Noni menjadi serbuk 

A Method of for Processing the Noni Plant into a Powder. United States Patent Application Ser.No.5,288,491. Moniz. USPTO 2004. (Not yet published).

60.  Ekstrak noni sebagai minuman berenergi atau suplemen makanan

Extract of Noni Fruit for Use as a Health-Improving Drink or Dietary Supplement. FR No. 2783137. (Not yet published).

H. MOLECULAR MECHANISM OF XERONINE & ANTIOXIDANT (Mekanisme molekuler dari xeronin dan antioksidan)

61.  Mengurangi kerusakan sel dalam tubuh

 Reducing Cellular Damage in the Human Body. International Publication Number WO 02/43664. Su Chen et al. PCT 2002; p.1-14.

62.  Xeronine, berguna dalam bidang kesehatan, makanan, dan industri

 Xeronine, a New Alkaloid, Useful in Medical, Food and Industrial Fields. United States Patent Application Ser.No. 4,543,212. Heincke, Ralph. USPTO 1985; p.1-28.

63. Efek Pencegahan dan Penghambatan terhadap mutagenesis dan karsinogenesis pada mamalia

Inhibitory and Preventative Effects of Processed Morinda citrifolia on mutagenesis and carcinogenesis in mammals. United States Patent Application Ser.No.2003157205. Jensen, Jarake et al. USPTO 2003; p.1-25.

Dengan berbagai publikasi ilmiah tersebut di atas, kiranya tidak berlebihan jika dikatakan bahwa buah Noni adalah anugerah terbaik dari Yang Maha Kuasa untuk kesehatan kita, di mana Tahitian Noni Bioactive Beverage (TNBB), dengan 52 paten dan 15 uji klinis, adalah suatu produk kesehatan yang luar biasa bermanfaat bagi kita semua.

Sumber : noniresearch.org